Tuskegee, Alabama holds a significant place in Black history for its association with the renowned Tuskegee Institute, now known as Tuskegee University. Founded in 1881 by Booker T. Washington, the Tuskegee Institute was one of the first colleges in the United States dedicated to providing higher education and vocational training for African Americans.

Under Washington's leadership, Tuskegee Institute became a leading institution for African American education, advocating for self-reliance, economic empowerment, and civic engagement. The institute played a key role in uplifting the Black community through its emphasis on practical skills and entrepreneurship.

Tuskegee is also known for the infamous Tuskegee Syphilis Study, a government-funded research project that began in 1932 and lasted until 1972. The study involved withholding treatment from African American men in Tuskegee who had syphilis, without their knowledge or consent, to observe the natural progression of the disease. The unethical nature of the study exposed deep-seated racism and discrimination in the medical research field and led to significant changes in research ethics and regulations.

Overall, Tuskegee, Alabama, holds a complex and important place in Black history, representing both the progress and challenges faced by African Americans in the United States.